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The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species

20 May 2024

Abstract excerpt

Triazoles, the most widely used class of antifungal drugs, inhibit the biosynthesis of ergosterol, a crucial component of the fungal plasma membrane. Inhibition of a separate ergosterol biosynthetic step, catalyzed by the sterol C-24 methyltransferase Erg6, reduces the virulence of pathogenic yeasts, but its effects on filamentous fungal pathogens like Aspergillus fumigatus remain unexplored. Here, we show that...

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PMID: 38769341
DOI: 10.1038/s41467-024-48767-3

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