Article
Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site.
Antimicrobial agents and chemotherapy - 1 Apr 2002
Jia N, Arthington-Skaggs B, Lee W, Pierson C A, Lees N D, Eckstein J, Barbuch R, Bard M
Abstract excerpt
The incidence of fungal infections has increased dramatically, which has necessitated additional and prolonged use of the available antifungal agents. Increased resistance to the commonly used antifungal agents, primarily the azoles, has been reported, thus necessitating the discovery and development of compounds that would be effective against the major human fungal pathogens. The sterol biosynthetic pathway has...
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