Article
A glycine-dependent riboswitch that uses cooperative binding to control gene expression.
Science (New York, N.Y.) - 8 Oct 2004
Mandal Maumita, Lee Mark, Barrick Jeffrey E, Weinberg Zasha, Emilsson Gail Mitchell, Ruzzo Walter L, Breaker Ronald R
Abstract excerpt
We identified a previously unknown riboswitch class in bacteria that is selectively triggered by glycine. A representative of these glycine-sensing RNAs from Bacillus subtilis operates as a rare genetic on switch for the gcvT operon, which codes for proteins that form the glycine cleavage system. Most glycine riboswitches integrate two ligand-binding domains that function cooperatively to more closely approximate...
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