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Article

The asymmetry and cooperativity of tandem glycine riboswitch aptamers.

RNA (New York, N.Y.) - 1 May 2020

Torgerson Chad D, Hiller David A, Strobel Scott A

Abstract excerpt

Glycine riboswitches utilize both single- and tandem-aptamer architectures. In the tandem system, the relative contribution of each aptamer toward gene regulation is not well understood. To dissect these contributions, the effects of 684 single mutants of a tandem ON switch from Bacillus subtilis were characterized for the wild-type construct and binding site mutations that selectively restrict ligand binding to...

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Share to Aptamers, Nucleotide
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31992591
DOI: 10.1261/rna.073577.119
PMCID: PMC7161355

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