Article
Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals.
Nucleic acids research - 1 Jul 2012
Qi Lei, Lucks Julius B, Liu Chang C, Mutalik Vivek K, Arkin Adam P
Abstract excerpt
Non-coding RNAs (ncRNAs) are versatile regulators in cellular networks. While most trans-acting ncRNAs possess well-defined mechanisms that can regulate transcription or translation, they generally lack the ability to directly sense cellular signals. In this work, we describe a set of design principles for fusing ncRNAs to RNA aptamers to engineer allosteric RNA fusion molecules that modulate the activity of...
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