Article
The Signaling Pathway That cGAMP Riboswitches Found: Analysis and Application of Riboswitches to Study cGAMP Signaling in Geobacter sulfurreducens.
International journal of molecular sciences - 21 Jan 2022
Tan Zhesen, Chan Chi Ho, Maleska Michael, Banuelos Jara Bryan, Lohman Brian K, Ricks Nathan J, Bond Daniel R, Hammond Ming C
Abstract excerpt
The Hypr cGAMP signaling pathway was discovered via the function of the riboswitch. In this study, we show the development of a method for affinity capture followed by sequencing to identify non-coding RNA regions that bind nucleotide signals such as cGAMP. The RNAseq of affinity-captured cGAMP riboswitches from the Geobacter sulfurreducens transcriptome highlights general challenges that remain for this...
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