Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2004

Krauthammer Michael, Kaufmann Charles A, Gilliam T Conrad, Rzhetsky Andrey

Abstract excerpt

A major challenge in human genetics is identifying the molecular basis of common heritable disorders. In contrast to rare single-gene diseases, multifactorial disorders are thought to arise from the combined effect of multiple gene variants, such that any single variant may have only a modest effect on disease susceptibility. We present a method to identify genes that may harbor a significant proportion of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Linkage

Share to Genetic Variation

Share to Genome, Human

Share to Models, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15471992
DOI: 10.1073/pnas.0404315101
PMCID: PMC523448

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular triangulation: bridging linkage and molecular-network information for identifying candidate genes in Alzheimer's disease.PMID 15471992Read ↗

Unbiased functional clustering of gene variants with a phenotypic-linkage network.Semantic proximity Read ↗

Broker genes in human disease.Semantic proximity Read ↗

Interactogeneous: Disease Gene Prioritization Using Heterogeneous Networks and Full Topology ScoresSemantic proximity Read ↗

Evolutionarily derived networks to inform disease pathways.Semantic proximity Read ↗

Network propagation of rare mutations in Alzheimer’s disease reveals tissue-specific hub genes and communitiesSemantic proximity Read ↗

networkGWAS: a network-based approach to discover genetic associations.Semantic proximity Read ↗

Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases.Semantic proximity Read ↗

Biological networks and GWAS: comparing and combining network methods to understand the genetics of familial breast cancer susceptibility in the GENESIS studySemantic proximity Read ↗

Network and pathway expansion of genetic disease associations identifies successful drug targetsSemantic proximity Read ↗

Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer.Semantic proximity Read ↗

Detecting genetic association through shortest paths in a bidirected graph.Semantic proximity Read ↗

Network propagation of rare variants in Alzheimer's disease reveals tissue-specific hub genes and communities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.