Article

Network and pathway expansion of genetic disease associations identifies successful drug targets

2020-04-23

Abstract excerpt

It is widely accepted that genetic evidence of disease association acts as a sound basis for the selection of drug targets for complex common diseases and that propagation of genetic evidence through gene or protein interaction networks can accurately infer novel disease associations at genes for which no direct genetic evidence can be observed. However, an empirical test of the utility of combining these beliefs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51bc6f0d-8dd9-5c6c-b2db-cb911d413c14
DOI: 10.1101/2020.04.22.051144

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Network and pathway expansion of genetic disease associations identifies successful drug targetsDOI 10.1101/2020.04.22.051144Read

Network and pathway expansion of genetic disease associations identifies successful drug targets.Semantic proximity Read

Pathway and network-based strategies to translate genetic discoveries into effective therapiesSemantic proximity Read

Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunitiesSemantic proximity Read

GWAS and drug targets.Semantic proximity Read

Benchmarking network propagation methods for disease gene identificationSemantic proximity Read

A Bayesian network-based framework to uncover the causal effects of genes on complex traits based on GWAS dataSemantic proximity Read

Multi-layered genetic approaches to identify approved drug targetsSemantic proximity Read

A Bayesian network-based framework to uncover the causal effects of genes on complex traits based on GWAS dataSemantic proximity Read

Bayesian inference of genetic pleiotropy identifies drug targets and repurposable medicines for human complex diseasesSemantic proximity Read

Prioritizing candidate disease genes by network-based boosting of genome-wide association data.Semantic proximity Read

Impact of proteogenomic evidence on clinical successSemantic proximity Read

Systematic Evaluation of Molecular Networks for Discovery of Disease Genes.Semantic proximity Read