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Article

Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer.

PLoS computational biology - 1 Mar 2021

Climente-González Héctor, Lonjou Christine, Lesueur Fabienne, Stoppa-Lyonnet Dominique, Andrieu Nadine, Azencott Chloé-Agathe

Abstract excerpt

Genome-wide association studies (GWAS) explore the genetic causes of complex diseases. However, classical approaches ignore the biological context of the genetic variants and genes under study. To address this shortcoming, one can use biological networks, which model functional relationships, to search for functionally related susceptibility loci. Many such network methods exist, each arising from different...

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Identifiers

PMID: 33735170
DOI: 10.1371/journal.pcbi.1008819
PMCID: PMC8009366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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