Article

Network propagation of rare mutations in Alzheimer’s disease reveals tissue-specific hub genes and communities

2019-09-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> State-of-the-art rare variant association testing methods aggregate the contribution of rare variants in biologically relevant genomic regions to boost statistical power. However, testing single genes separately does not consider the complex interaction landscape of genes, nor the downstream effects of non-synonymous variants on protein structure and function. Here we presen...

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Literature Corpus work: d2e4cb69-57ca-5036-a23a-ff28d3fbca48
DOI: 10.1101/781203

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