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Article

PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2006

Strathmann Julia, Schwarz Michael, Tharappel Job C, Glauert Howard P, Spear Brett T, Robertson Larry W, Appel Klaus E, Buchmann Albrecht

Abstract excerpt

Polychlorinated biphenyls (PCBs) are ubiquitous environmental toxicants which act as liver tumor promoters in rodents and can be classified as either dioxin-like or non-dioxin (phenobarbital [PB])-like inducers of cytochrome P-450. Since we have previously shown that tumor promotion by PB leads to clonal outgrowth of beta-catenin (Catnb)-mutated but not Ha-ras-mutated mouse liver tumors, we were interested to...

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Identifiers

PMID: 16782779
DOI: 10.1093/toxsci/kfl041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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