Article
High prevalence of diabetes-specific autoimmunity in first-degree relatives of Sardinian patients with type 1 diabetes.
Diabetes/metabolism research and reviews - 1 Mar 2017
Incani M, Serafini C, Satta C, Perra L, Scano F, Frongia P, Ricciardi R, Ripoli C, Soro M, Strazzera A, Zampetti S, Buzzetti R, Cavallo M G, Cossu E, Baroni M G
Abstract excerpt
BACKGROUND: The incidence of type 1 diabetes mellitus (T1DM) in Sardinia is among the highest in the world (44.8 cases/100,000 person-years). Recommendations of the Immunology of Diabetes Society advise evaluating autoantibody positivity in first-degree relatives (FDRs) of patients with T1DM, for their higher risk to develop the disease. The aim of this study was to determine the prevalence of beta-cell...
Topics
- Adolescent
- Adult
- Autoantibodies
- Autoimmune Diseases
- Autoimmunity
- Biomarkers
- Child
- Diabetes Mellitus, Type 1
- Family
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- HLA-DQ Antigens