Article
Multiple sequences in the C terminus of MaxiK channels are involved in expression, movement to the cell surface, and apical localization.
Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2004
Kwon Sang-Ho, Guggino William B
Abstract excerpt
Apical expression of the large-conductance, calcium- and voltage-activated potassium (MaxiK) channel in the cortical collecting duct is responsible for flow-stimulated potassium secretion. Here, we identify two cytoplasmic regions controlling apical expression of the MaxiK channel. Disruption of the proximal region results in the intracellular retention of the MaxiK channel without affecting channel assembly,...
Topics
- Animals
- Biological Transport, Active
- COS Cells
- Cell Membrane
- Cytoplasm
- Endoplasmic Reticulum
- Gene Expression
- Large-Conductance Calcium-Activated Potassium Channels
- Mutation
- Potassium Channels, Calcium-Activated
- Protein Structure, Quaternary
- Recombinant Proteins
- Sequence Deletion