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Article

Activation of renal ClC-K chloride channels depends on an intact N terminus of their accessory subunit barttin.

The Journal of biological chemistry - 1 Jun 2018

Wojciechowski Daniel, Thiemann Stefan, Schaal Christina, Rahtz Alina, de la Roche Jeanne, Begemann Birgit, Becher Toni, Fischer Martin

Abstract excerpt

ClC-K channels belong to the CLC family of chloride channels and chloride/proton antiporters. They contribute to sodium chloride reabsorption in Henle's loop of the kidney and to potassium secretion into the endolymph by the stria vascularis of the inner ear. Their accessory subunit barttin stabilizes the ClC-K/barttin complex, promotes its insertion into the surface membrane, and turns the pore-forming subunits...

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Source

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Identifiers

PMID: 29674316
DOI: 10.1074/jbc.RA117.000860
PMCID: PMC5986197

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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