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Article

The important role for betaVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor.

Journal of human genetics - 1 Jan 2004

Iwasaki Tadao, Takahashi Sadao, Ishihara Mitsuaki, Takahashi Masafumi, Ikeda Uichi, Shimada Kazuyuki, Fujino Takahiro, Yamamoto Tokuo T, Hattori Hiroaki, Emi Mitsuru

Abstract excerpt

The low-density lipoprotein (LDL) receptor (LDLR) is a crucial role for binding and uptaking apolipoprotein (apo) B-containing lipoproteins, such as very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and LDL. The defect function of the LDLR causes familial hypercholesterolemia (FH), the phenotype of which is elevated plasma cholesterol and premature coronary heart disease (CHD). In the...

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PMID: 15459764
DOI: 10.1007/s10038-004-0198-4

Genes

LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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