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Article

Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.

Journal of lipid research - 1 Dec 2013

Fotakis Panagiotis, Tiniakou Ioanna, Kateifides Andreas K, Gkolfinopoulou Christina, Chroni Angeliki, Stratikos Efstratios, Zannis Vassilis I, Kardassis Dimitris

Abstract excerpt

We studied the significance of four hydrophobic residues within the 225-230 region of apoA-I on its structure and functions and their contribution to the biogenesis of HDL. Adenovirus-mediated gene transfer of an apoA-I[F225A/V227A/F229A/L230A] mutant in apoA-I⁻/⁻ mice decreased plasma cholesterol, HDL cholesterol, and apoA-I levels. When expressed in apoA-I⁻/⁻ × apoE⁻/⁻ mice, approximately 40% of the mutant...

Topics

Adenoviridae
Animals
Apolipoprotein A-I
Chemical Phenomena
HEK293 Cells
Humans
Hydrophobic and Hydrophilic Interactions
Lipoproteins, HDL
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 24123812
DOI: 10.1194/jlr.M043489
PMCID: PMC3826677

Genes

LCAT
ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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