Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.

Nature - 14 Aug 1997

Fass D, Blacklow S, Kim P S, Berger J M

Abstract excerpt

The low-density lipoprotein receptor (LDLR) is responsible for the uptake of cholesterol-containing lipoprotein particles into cells. The amino-terminal region of LDLR, which consists of seven tandemly repeated, approximately 40-amino-acid, cysteine-rich modules (LDL-A modules), mediates binding to lipoproteins. LDL-A modules are biologically ubiquitous domains, found in over 100 proteins in the sequence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Amino Acid Sequence
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crystallography, X-Ray

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Protein Conformation

Share to Receptors, LDL

Source

Identifiers

PMID: 9262405
DOI: 10.1038/41798

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.PMID 9262405Read ↗

Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions.Semantic proximity Read ↗

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.Semantic proximity Read ↗

Molecular modeling of D151Y and M391T mutations in the LDL receptor.Semantic proximity Read ↗

Exploring the complete mutational space of the LDL receptor LA5 domain using molecular dynamics: linking SNPs with disease phenotypes in familial hypercholesterolemia.Semantic proximity Read ↗

Activity-associated effect of LDL receptor missense variants located in the cysteine-rich repeats.Semantic proximity Read ↗

Solution structure of the LDL receptor EGF-AB pair: a paradigm for the assembly of tandem calcium binding EGF domains.Semantic proximity Read ↗

Low-density lipoprotein receptor structure and folding.Semantic proximity Read ↗

The mammalian low-density lipoprotein receptor family.Semantic proximity Read ↗

Mutation mapping of apolipoprotein A-I structure assisted with the putative cholesterol recognition regions.Semantic proximity Read ↗

Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.Semantic proximity Read ↗

Familial hypercholesterolemia: dissection of a receptor disease.Semantic proximity Read ↗

Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein ReceptorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.