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Article

Identification of a VLDL-induced, FDNPVY-independent internalization mechanism for the LDLR.

The EMBO journal - 25 Jul 2007

Michaely Peter, Zhao Zhenze, Li Wei-Ping, Garuti Rita, Huang Lily J, Hobbs Helen H, Cohen Jonathan C

Abstract excerpt

The low-density lipoprotein (LDL) receptor (LDLR) binds to and internalizes lipoproteins that contain apolipoproteinB100 (apoB100) or apolipoproteinE (apoE). Internalization of the apoB100 lipoprotein ligand, LDL, requires the FDNPVY(807) sequence on the LDLR cytoplasmic domain, which binds to the endocytic machinery of coated pits. We show here that inactivation of the FDNPVY(807) sequence by mutation of Y807 to...

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Identifiers

PMID: 17581630
DOI: 10.1038/sj.emboj.7601769
PMCID: PMC1933400

Genes

LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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