Article
Characterization of apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), a mutant apolipoprotein E associated with hyperlipidemia and atherosclerosis.
Journal of lipid research - 1 Feb 1999
Yamamura T, Dong L M, Yamamoto A
Abstract excerpt
Previously, a mutant apolipoprotein (apo) E, apolipoprotein E7 (Glu(244)-->Lys, Glu(245)--->Lys), has been identified in association with hyperlipidemia and atherosclerosis. To investigate the effects of its structural changes on lipoprotein metabolisms and its correlation with atherosclerosis, w...
Topics
- Apolipoprotein E3
- Apolipoproteins E
- Arteriosclerosis
- Binding, Competitive
- Cells, Cultured
- Cholesterol
- Chromatography, Gel
- Fibroblasts
- Heparin
- Humans
- Hyperlipidemias
- Iodine Radioisotopes
- Isoelectric Focusing
- Lipoproteins
- Phenotype
- Point Mutation
- Protein Binding
- Receptors, LDL