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Article

Searching for polymorphisms that affect gene expression and mRNA processing: example ABCB1 (MDR1).

The AAPS journal - 18 Aug 2006

Wang Danxin, Sadée Wolfgang

Abstract excerpt

Cis-acting genetic variations can affect the amount and structure of mRNA/protein. Genomic surveys indicate that polymorphisms affecting transcription and mRNA processing, including splicing and turnover, may account for the main share of genetic factors in human phenotypic variability; however, most of these polymorphisms remain yet to be discovered. We use allelic expression imbalance (AEI) as a quantitative...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HTT gene

Share to OPRM1 gene

Share to Polymorphism, Genetic

Share to Polymorphism, Single Nucleotide

Share to RNA, Messenger

Share to RNA Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 17025270
DOI: 10.1208/aapsj080361
PMCID: PMC2761059

Genes

ABCB1
HTT
OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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