Article
Phenotype-genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles.
Biochemical and biophysical research communications - 9 Dec 2005
Rodríguez-Antona Cristina, Sayi Jane G, Gustafsson Lars L, Bertilsson Leif, Ingelman-Sundberg Magnus
Abstract excerpt
The human cytochrome P450 3A (CYP3A) enzymes, which metabolize 50% of currently used therapeutic drugs, exhibit great interindividual differences in activity that have a major impact on drug treatment outcome, but hitherto no genetic background importantly contributing to this variation has been identified. In this study we show that CYP3A4 mRNA and hnRNA contents with a few exceptions vary in parallel in human...
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