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Article

A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels.

Development (Cambridge, England) - 1 Oct 2004

Hallaq Haifa, Pinter Emese, Enciso Josephine, McGrath James, Zeiss Caroline, Brueckner Martina, Madri Joseph, Jacobs Harris C, Wilson Christine M, Vasavada Hemaxi, Jiang Xiaobing, Bogue Clifford W

Abstract excerpt

The homeobox gene Hhex has recently been shown to be essential for normal liver, thyroid and forebrain development. Hhex(-/-) mice die by mid-gestation (E14.5) and the cause of their early demise remains unclear. Because Hhex is expressed in the developing blood islands at E7.0 in the endothelium...

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Source

Identifiers

PMID: 15459110
DOI: 10.1242/dev.01393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15459110-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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