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Article

Hyperplastic conotruncal endocardial cushions and transposition of great arteries in perlecan-null mice.

Circulation research - 26 Jul 2002

Costell Mercedes, Carmona Rita, Gustafsson Erika, González-Iriarte Mauricio, Fässler Reinhard, Muñoz-Chápuli Ramón

Abstract excerpt

Perlecan is a heparan-sulfate proteoglycan abundantly expressed in pericellular matrices and basement membranes during development. Inactivation of the perlecan gene in mice is lethal at two developmental stages: around E10 and around birth. We report a high incidence of malformations of the cardiac outflow tract in perlecan-deficient embryos. Complete transposition of great arteries was diagnosed in 11 out of 15...

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Source

Identifiers

PMID: 12142349
DOI: 10.1161/01.res.0000026056.81424.da

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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