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Article

Bmp signaling represses Vegfa to promote outflow tract cushion development.

Development (Cambridge, England) - 1 Aug 2013

Bai Yan, Wang Jun, Morikawa Yuka, Bonilla-Claudio Margarita, Klysik Elzbieta, Martin James F

Abstract excerpt

Congenital heart disease (CHD) is a devastating anomaly that affects ∼1% of live births. Defects of the outflow tract (OFT) make up a large percentage of human CHD. We investigated Bmp signaling in mouse OFT development by conditionally deleting both Bmp4 and Bmp7 in the second heart field (SHF). SHF Bmp4/7 deficiency resulted in defective epithelial to mesenchymal transition (EMT) and reduced cardiac neural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23863481
DOI: 10.1242/dev.097360
PMCID: PMC3737720

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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