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Article

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.

Nature - 12 Mar 1992

Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel M O, Lesage S, Vionnet N, Clément K, Fougerousse F

Abstract excerpt

Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify, the gene(s) predisposing to NIDDM. Here we report linkage between the glucokinase locus on...

Topics

Adenosine Deaminase
Base Sequence
Blood Glucose
Chromosomes, Human, Pair 7
DNA
Diabetes Mellitus, Type 2
Genetic Linkage
Glucokinase
Humans
Lod Score
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Monosaccharide Transport Proteins

Mutation

Pedigree

Polymerase Chain Reaction

Source

Identifiers

PMID: 1545870
DOI: 10.1038/356162a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1545870-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.PMID 1545870Read ↗

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Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.Semantic proximity Read ↗

Linkage analysis and molecular scanning of glucokinase gene in NIDDM families.Semantic proximity Read ↗

Linkage of type 2 diabetes to the glucokinase gene.Semantic proximity Read ↗

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Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees.Semantic proximity Read ↗

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Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.Semantic proximity Read ↗

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