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Article

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.

Nature - 12 Mar 1992

Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel M O, Lesage S, Vionnet N, Clément K, Fougerousse F

Abstract excerpt

Non-insulin-dependent diabetes mellitus (NIDDM) is a major health problem, affecting 5% of the world population. Genetic factors are important in NIDDM, but the mechanisms leading to glucose intolerance are unknown. Genetic linkage has been investigated in multigeneration families to localize, and ultimately identify, the gene(s) predisposing to NIDDM. Here we report linkage between the glucokinase locus on...

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PMID: 1545870
DOI: 10.1038/356162a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.PMID 1545870Read ↗

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Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.Semantic proximity Read ↗

Linkage analysis and molecular scanning of glucokinase gene in NIDDM families.Semantic proximity Read ↗

Linkage of type 2 diabetes to the glucokinase gene.Semantic proximity Read ↗

Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.Semantic proximity Read ↗

Maturity-onset diabetes of the young.Semantic proximity Read ↗

Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees.Semantic proximity Read ↗

A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase geneSemantic proximity Read ↗

Indication for genetic linkage of the phosphoenolpyruvate carboxykinase (PCK1) gene region on chromosome 20q to non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Candidate gene studies in pedigrees with maturity-onset diabetes of the young not linked with glucokinase.Semantic proximity Read ↗

[Glucokinase gene abnormalities in maturity-onset diabetes of the young (MODY) and late-onset NIDDM].Semantic proximity Read ↗

Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.Semantic proximity Read ↗

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