Article
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.
Nature - 23 Apr 1992
Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell G I, Zouali H, Lesage S, Velho G, Iris F, Passa P
Abstract excerpt
Maturity-onset diabetes of the young (MODY) is a form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM) which is characterized by an early age at onset and an autosomal dominant mode of inheritance. Except for these features, the clinical characteristics of patients with MODY are simila...
Topics
- Base Sequence
- Chromosomes, Human, Pair 7
- DNA Probes
- Diabetes Mellitus, Type 2
- Female
- Genetic Linkage
- Glucokinase
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic