Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.

doi:10.1038/ng0695-240

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Article

Linkage and association between insulin-dependent diabetes mellitus (IDDM) susceptibility and markers near the glucokinase gene on chromosome 7.

Nature genetics - 1 Jun 1995

Rowe R E, Wapelhorst B, Bell G I, Risch N, Spielman R S, Concannon P

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) is characterized by autoimmune destruction of the insulin secreting beta-cells of the pancreas and subsequent disruption of glucose metabolism. The tendency of IDDM to cluster in families and the modest (36%) concordance rate in monozygotic twins indicat...

Topics

Alleles
Chromosomes, Human, Pair 7
DNA, Satellite
Diabetes Mellitus, Type 1
Disease Susceptibility
Female
Genetic Linkage
Genetic Markers
Glucokinase
Haplotypes
Humans
Male

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