Article
Linkage analysis and molecular scanning of glucokinase gene in NIDDM families.
Diabetes - 1 Sept 1993
Zouali H, Vaxillaire M, Lesage S, Sun F, Velho G, Vionnet N, Chiu K, Passa P, Permutt A, Demenais F
Abstract excerpt
Mutations in the glucokinase gene are a major cause of maturity-onset diabetes of the young. To evaluate the contribution of this gene to the development of late-onset NIDDM, linkage analyses between DNA polymorphisms at the glucokinase locus and NIDDM were performed in 79 multigenerational Frenc...
Topics
- Adolescent
- Adult
- Aged
- Base Sequence
- Child
- DNA, Single-Stranded
- Diabetes Mellitus, Type 2
- Female
- Genetic Linkage
- Glucokinase
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Genetic