Article
Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential.
Molecular and cellular biology - 1 Mar 1992
Tratner I, Ofir R, Verma I M
Abstract excerpt
We have studied the phosphorylation of the nuclear oncoprotein Fos by cyclic AMP-dependent protein kinase (PKA). We demonstrate that the human c-Fos protein, phosphorylated either in vitro with purified PKA or in vivo in JEG3 cells following treatment with forskolin, has similar phosphotryptic pe...
Topics
- Amino Acid Sequence
- Cell Transformation, Neoplastic
- Colforsin
- Electrophoresis, Gel, Two-Dimensional
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Precipitin Tests
- Protein Kinases
- Proto-Oncogene Proteins c-fos
- Substrate Specificity
- Tumor Cells, Cultured