Article
The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells.
The EMBO journal - 16 Oct 1995
Okazaki K, Sagata N
Abstract excerpt
The c-mos proto-oncogene product, Mos, is a serine/threonine kinase that can activate ERK1 and 2 mitogen-activated protein (MAP) kinases by direct phosphorylation of MAPK/ERK kinase (MEK). ERK activation is essential for oncogenic transformation of NIH 3T3 cells by Mos. In this study, we examined...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Nucleus
- Cell Transformation, Neoplastic
- Cloning, Molecular
- Immunoblotting
- Mice
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins
- Phosphorylation
- Precipitin Tests
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-mos
- Recombinant Proteins