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Article

A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei.

Molecular and cellular biology - 1 Mar 1992

Paindavoine P, Rolin S, Van Assel S, Geuskens M, Jauniaux J C, Dinsart C, Huet G, Pays E

Abstract excerpt

The bloodstream form of Trypanosoma brucei contains transcripts of at least four genes showing partial sequence homology to the genes for eucaryotic adenylate and guanylate cyclases (S. Alexandre, P. Paindavoine, P. Tebabi, A. Pays, S. Halleux, M. Steinert, and E. Pays, Mol. Biochem. Parasitol. 43:279-288, 1990). One of these genes, termed ESAG 4, belongs to the polycistronic transcription unit of the variant...

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Identifiers

PMID: 1545803
DOI: 10.1128/mcb.12.3.1218-1225.1992
PMCID: PMC369553

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A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei.PMID 1545803Read ↗

Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4‐like subfamilySemantic proximity Read ↗

The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.Semantic proximity Read ↗

A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant surface glycoprotein gene expression site.Semantic proximity Read ↗

Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.Semantic proximity Read ↗

Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei.Semantic proximity Read ↗

Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.Semantic proximity Read ↗

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Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream.Semantic proximity Read ↗

Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.Semantic proximity Read ↗

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei.Semantic proximity Read ↗

Mutational analysis of the variant surface glycoprotein GPI-anchor signal sequence in Trypanosoma brucei.Semantic proximity Read ↗

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