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Article

Structural features affecting variant surface glycoprotein expression in Trypanosoma brucei.

Molecular and biochemical parasitology - 1 May 2003

Wang Jun, Böhme Ulrike, Cross George A M

Abstract excerpt

The glycosylphosphatidylinositol (GPI)-anchored variant surface glycoprotein (VSG) of Trypanosoma brucei is the most abundant GPI-anchored protein expressed on any cell, and is an essential virulence factor. To determine what structural features affect efficient expression of VSG, we made a series of mutations in two VSGs. Inserting 18 amino acids, between the amino- and carboxy-terminal domains, reduced the...

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Source

Identifiers

PMID: 12742580
DOI: 10.1016/s0166-6851(03)00055-0

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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