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Article

Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.

PloS one - 26 Oct 2009

Smith Terry K, Vasileva Nadina, Gluenz Eva, Terry Stephen, Portman Neil, Kramer Susanne, Carrington Mark, Michaeli Shulamit, Gull Keith, Rudenko Gloria

Abstract excerpt

BACKGROUND: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesis by the induction of VSG RNAi triggers an unu...

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Identifiers

PMID: 19855834
DOI: 10.1371/journal.pone.0007532
PMCID: PMC2762041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19855834-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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