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Article

The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.

The EMBO journal - 1 Aug 1991

Ross D T, Raibaud A, Florent I C, Sather S, Gross M K, Storm D R, Eisen H

Abstract excerpt

African trypanosomes are protozoan parasites that evade the host immune system by varying their dense antigenic coat. The Variant Surface Glycoprotein (VSG) is expressed exclusively from telomere-linked expression sites that contain in addition to the VSG gene, a number of open reading frames termed Expression Site Associated Genes (ESAGs). Here we demonstrate by complementation of a yeast mutant deleted for...

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Identifiers

PMID: 2065652
DOI: 10.1002/j.1460-2075.1991.tb07735.x
PMCID: PMC452886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.PMID 2065652Read ↗

Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4‐like subfamilySemantic proximity Read ↗

A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei.Semantic proximity Read ↗

Delineation of the regulated Variant Surface Glycoprotein gene expression site domain of Trypanosoma brucei.Semantic proximity Read ↗

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Metacyclic VSG expression site promoters are recognized by the same general transcription factor that is required for RNA polymerase I transcription of bloodstream expression sites.Semantic proximity Read ↗

Molecular cloning of the tsm0185 gene responsible for adenylate cyclase activity in Saccharomyces cerevisiae.Semantic proximity Read ↗

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Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma brucei.Semantic proximity Read ↗

A VSG Expression Site–Associated Gene Confers Resistance to Human Serum in Trypanosoma rhodesienseSemantic proximity Read ↗

Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum.Semantic proximity Read ↗

Identification of regulatory residues of the yeast adenylyl cyclase.Semantic proximity Read ↗

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