Article
The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.
The EMBO journal - 1 Aug 1991
Ross D T, Raibaud A, Florent I C, Sather S, Gross M K, Storm D R, Eisen H
Abstract excerpt
African trypanosomes are protozoan parasites that evade the host immune system by varying their dense antigenic coat. The Variant Surface Glycoprotein (VSG) is expressed exclusively from telomere-linked expression sites that contain in addition to the VSG gene, a number of open reading frames termed Expression Site Associated Genes (ESAGs). Here we demonstrate by complementation of a yeast mutant deleted for...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Northern
- Gene Expression Regulation, Enzymologic
- Genes, Fungal
- Genes, Regulator
- Leucine
- Molecular Sequence Data
- Mutation