Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.

doi:10.1128/mcb.12.3.1007-1020.1992

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Article

Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.

Molecular and cellular biology - 1 Mar 1992

Short M K, Clouthier D E, Schaefer I M, Hammer R E, Magnuson M A, Beale E G

Abstract excerpt

The cytosolic phosphoenolpyruvate carboxykinase (PEPCK) gene is expressed in multiple tissues and is regulated in a complex tissue-specific manner. To map the cis-acting DNA elements that direct this tissue-specific expression, we made transgenic mice containing truncated PEPCK-human growth hormone (hGH) fusion genes. The transgenes contained PEPCK promoter fragments with 5' endpoints at -2088, -888, -600, -402,...

Topics

Adipose Tissue
Animals
Base Sequence
Blotting, Northern
Cloning, Molecular
DNA
Diet
Gene Expression Regulation, Enzymologic
Glucocorticoids
Growth Hormone
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Kidney

Liver

Mice

Mice, Transgenic

Molecular Sequence Data

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 1545785
DOI: 10.1128/mcb.12.3.1007-1020.1992
PMCID: PMC369533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1545785-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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