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Article

Promoter elements that mediate the pH response of PCK mRNA in LLC-PK1-F+ cells.

The American journal of physiology - 1 Aug 1996

Holcomb T, Liu W, Snyder R, Shapiro R, Curthoys N P

Abstract excerpt

The onset of metabolic acidosis causes an increased transcription of the renal phosphoenolpyruvate carboxykinase (PCK) gene. When transgenic mice carrying a bovine growth hormone (bGH) gene driven by the -460 to +73 segment of the PCK promoter were made chronically acidotic, the bGH mRNA was increased twofold after 4 days. Confluent and well-differentiated cultures of LLC-PK1-F+ cells exhibit a 2.5-fold increase...

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Source

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PMID: 8770165
DOI: 10.1152/ajprenal.1996.271.2.F340

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CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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