Article
An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice.
The Journal of biological chemistry - 25 Feb 1994
Patel Y M, Yun J S, Liu J, McGrane M M, Hanson R W
Abstract excerpt
Sequences in the gene for P-enolpyruvate carboxykinase (PEPCK) which are responsible for its complex pattern of transcriptional control were determined using transgenic mice containing a chimeric PEPCK-bovine growth hormone (bGH) gene consisting of a segment of the PEPCK promoter from -460 to +73, with mutations in specific regulatory domains. A mutation in the cAMP response element (CRE) (-87 to -74), which...
Topics
- Animals
- Cyclic AMP
- Diet
- Gene Expression Regulation, Enzymologic
- Growth Hormone
- Liver
- Mice
- Mice, Transgenic
- Mutation
- Phosphoenolpyruvate Carboxykinase (GTP)