Cis-regulatory elements that confer differential expression upon the rat gene encoding phosphoenolpyruvate carboxykinase in kidney and liver.

doi:10.1016/0378-1119(91)90424-a

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cis-regulatory elements that confer differential expression upon the rat gene encoding phosphoenolpyruvate carboxykinase in kidney and liver.

Gene - 30 May 1991

Shoshani T, Benvenisty N, Trus M, Reshef L

Abstract excerpt

The PCK gene, encoding cytosolic phosphoenolpyruvate carboxykinase, is specifically expressed in gluconeogenic tissues, liver and kidney. Hence it serves as a model of a class of single-copy genes whose transcription is restricted to a few tissues, rather than a unique tissue. To begin delineating the mechanisms that govern this pattern of expression, cis-regulatory elements of PCK were examined using transient...

Topics

Animals
CCAAT-Enhancer-Binding Proteins
Cell Line
Chromosome Deletion
Cytosol
DNA-Binding Proteins
Gene Expression Regulation, Enzymologic
Kidney
Liver
Liver Neoplasms, Experimental
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NFI Transcription Factors

Nuclear Proteins

Phosphoenolpyruvate Carboxylase

Promoter Regions, Genetic

Rats

Swine

Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 2055492
DOI: 10.1016/0378-1119(91)90424-a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2055492-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cis-regulatory elements that confer differential expression upon the rat gene encoding phosphoenolpyruvate carboxykinase in kidney and liver.PMID 2055492Read ↗

Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.Semantic proximity Read ↗

The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene.Semantic proximity Read ↗

Factors interacting with the rat carbamyl phosphate synthetase promoter in expressing and nonexpressing tissues.Semantic proximity Read ↗

Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation.Semantic proximity Read ↗

In vitro analysis of promoter elements regulating transcription of the phosphoenolpyruvate carboxykinase (GTP) gene.Semantic proximity Read ↗

Transcriptional regulation of the phosphoenolpyruvate carboxykinase gene by cooperation between hepatic nuclear factors.Semantic proximity Read ↗

An analysis of regulatory elements in the phosphoenolpyruvate carboxykinase (GTP) gene which are responsible for its tissue-specific expression and metabolic control in transgenic mice.Semantic proximity Read ↗

Carbohydrate regulation of hepatic gene expression. Evidence against a role for the upstream stimulatory factor.Semantic proximity Read ↗

SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver.Semantic proximity Read ↗

Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element.Semantic proximity Read ↗

Characterization of cis-elements mediating the stimulation of glucose-6-phosphate transporter promoter activity by glucocorticoids.Semantic proximity Read ↗

Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.