Article
Characterization of the factors binding to a PEPCK gene upstream hypersensitive site with LCR activity.
Nucleic acids research - 11 Jul 1992
Cheyette T E, Ip T, Faber S, Matsui Y, Chalkley R
Abstract excerpt
A previously described upstream hypersensitive site (HS) in the PEPCK gene at -4800 bp, termed HS A (1), has been characterized and determined to bind at least two factors. One of these is a member of the ubiquitous CREB/ATF family, and the second is a novel tissue specific protein, pep A. A construct carrying HS A and the PEPCK proximal promoter was tested in transgenic mice and its CAT activity compared to the...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides