Article
The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept.
Arthritis and rheumatism - 1 Sept 2004
Criswell Lindsey A, Lum Raymond F, Turner Kevin N, Woehl Blanche, Zhu Yuanqing, Wang Jinyi, Tiwari Hemant K, Edberg Jeffrey C, Kimberly Robert P, Moreland Larry W, Seldin Michael F, Bridges S Louis
Abstract excerpt
OBJECTIVE: To examine the roles of specific genetic polymorphisms as predictors of response to treatment of early rheumatoid arthritis (RA). METHODS: Subjects included 457 patients with early RA (duration of < or =3 years) who participated in a randomized controlled trial comparing weekly methotrexate and 2 dosages of etanercept (10 mg twice weekly and 25 mg twice weekly). Our primary outcome measure was...
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