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Article

Influence of the shared epitope on the effectiveness of biologic antirheumatic agents in European patients with rheumatoid arthritis.

RMD open - 9 Jul 2026

Finckh Axel, Courvoisier Delphine S, Aymon Romain, Mongin Denis, Saevarsdottir Saedis, Jonsdottir Ingileif, Stefansson Kari, Hetland Merete Lund, Moeller Burkhard, Villard Jean, Lauper Kim, Glintborg Bente

Abstract excerpt

BACKGROUND: For rheumatoid arthritis (RA), the HLA-DRB1 'shared epitope' (SE) allele has been proposed as a predictive biomarker for the effectiveness of mainly abatacept and other biologic disease-modifying antirheumatic drugs (bDMARDs). OBJECTIVE: To explore the relative impact of SE positivity on the effectiveness of different bDMARDs in European patients with RA. METHODS: Nested cohort study in the Swiss...

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Share to Abatacept
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antirheumatic Agents

Share to Biological Products

Share to Epitopes

Share to HLA-DRB1 Chains

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Source

Open in PubMed Open full text

Identifiers

PMID: 42425718
DOI: 10.1136/rmdopen-2026-006788
PMCID: PMC13358348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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