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Article

A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Apr 2008

Miceli-Richard C, Comets E, Verstuyft C, Tamouza R, Loiseau P, Ravaud P, Kupper H, Becquemont L, Charron D, Mariette X

Abstract excerpt

OBJECTIVE: To determine whether tumour necrosis factor (TNF) gene polymorphisms and/or the shared epitope are genetic predictors of the response to adalimumab (ADA) in rheumatoid arthritis (RA). METHODS: This ancillary study to the Research in Active Rheumatoid Arthritis (ReAct) Phase IIIb study included a large cohort of Caucasian patients with RA from France (n = 388) treated with ADA plus methotrexate (MTX) (n...

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Topics

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Share to Adalimumab
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antirheumatic Agents

Share to Arthritis, Rheumatoid

Share to Drug Therapy, Combination

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Methotrexate

Source

Open in PubMed Open full text

Identifiers

PMID: 17673491
DOI: 10.1136/ard.2007.074104
PMCID: PMC2750008

Genes

ADA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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