Article
The SERCA residue Glu340 mediates interdomain communication that guides Ca2+ transport.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 2020
Geurts Maxwell M G, Clausen Johannes D, Arnou Bertrand, Montigny Cédric, Lenoir Guillaume, Corey Robin A, Jaxel Christine, Møller Jesper V, Nissen Poul, Andersen Jens Peter, le Maire Marc, Bublitz Maike
Abstract excerpt
The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) is a P-type ATPase that transports Ca2+ from the cytosol into the sarco(endo)plasmic reticulum (SR/ER) lumen, driven by ATP. This primary transport activity depends on tight coupling between movements of the transmembrane helices forming the two Ca2+-binding sites and the cytosolic headpiece mediating ATP hydrolysis. We have addressed the molecular basis for...
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