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Article

Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively.

American journal of physiology. Cell physiology - 1 Jan 2005

Lai Yurong, Lee Eun-Woo, Ton Carl C, Vijay Shashi, Zhang Huixia, Unadkat Jashvant D

Abstract excerpt

The functional significance of two highly conserved amino acid residues, F316 [putative transmembrane domain (TM)7] and G476 (putative TM11), in the concentrative nucleoside transporter hCNT1 (SLC28A1) was examined by performing site-directed mutagenesis. Conservative mutations at these positions (F316A, F316Y, G476A, and G476L) were generated and expressed in Madin-Darby canine kidney (MDCK) cells as fusion...

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PMID: 15456697
DOI: 10.1152/ajpcell.00192.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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