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Article

A proton-mediated conformational shift identifies a mobile pore-lining cysteine residue (Cys-561) in human concentrative nucleoside transporter 3.

The Journal of biological chemistry - 28 Mar 2008

Slugoski Melissa D, Ng Amy M L, Yao Sylvia Y M, Smith Kyla M, Lin Colin C, Zhang Jing, Karpinski Edward, Cass Carol E, Baldwin Stephen A, Young James D

Abstract excerpt

The concentrative nucleoside transporter (CNT) protein family in humans is represented by three members, hCNT1, hCNT2, and hCNT3. Belonging to a CNT subfamily phylogenetically distinct from hCNT1/2, hCNT3 mediates transport of a broad range of purine and pyrimidine nucleosides and nucleoside drug...

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Identifiers

PMID: 18199742
DOI: 10.1074/jbc.M710433200
PMCID: PMC2417190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18199742-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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