Article
Disrupted plasma membrane localization and loss of function reveal regions of human equilibrative nucleoside transporter 1 involved in structural integrity and activity.
Biochimica et biophysica acta - 1 Oct 2009
Nivillac Nicole M I, Wasal Karanvir, Villani Daniela F, Naydenova Zlatina, Hanna W J Brad, Coe Imogen R
Abstract excerpt
Human Equilibrative Nucleoside Transporter 1 (hENT1) is an integral membrane protein that transports nucleosides and analog drugs across cellular membranes. Very little is known about intracellular processing and localization of hENT1. Here we show that disruption of a highly conserved triplet (P...
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