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Article

Mutation of Trp29 of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity.

The Biochemical journal - 1 Sept 2008

Paproski Robert J, Visser Frank, Zhang Jing, Tackaberry Tracey, Damaraju Vijaya, Baldwin Stephen A, Young James D, Cass Carol E

Abstract excerpt

hENT1 (human equilibrative nucleoside transporter 1) is inhibited by nanomolar concentrations of various structurally distinct coronary vasodilator drugs, including dipyridamole, dilazep, draflazine, soluflazine and NBMPR (nitrobenzylmercaptopurine ribonucleoside). When a library of randomly mutated hENT1 cDNAs was screened using a yeast-based functional complementation assay for resistance to dilazep, a clone...

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PMID: 18462193
DOI: 10.1042/BJ20080074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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