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Article

Are there multiple pathways in the pathogenesis of Huntington'sdisease?

29 Jun 1999

Abstract excerpt

Studies of huntingtin localization in human post-mortem brain offer insights and a framework for basic experiments in the pathogenesis of Huntington's disease. In neurons of cortex and striatum, we identified changes in the cytoplasmic localization of huntingtin including a marked perinuclear accumulation of huntingtin and formation of multivesicular bodies, changes conceivably pointing to an altered handling of...

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Identifiers

PMID: 10434298
DOI: 10.1098/rstb.1999.0451

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