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Article

Estrogen metabolism genotypes, use of long-term hormone replacement therapy and risk of postmenopausal breast cancer.

Oncology reports - 1 Aug 2011

Cerne Jasmina Ziva, Novakovic Srdjan, Frkovic-Grazio Snjezana, Pohar-Perme Maja, Stegel Vida, Gersak Ksenija

Abstract excerpt

Association between long-term hormone replacement therapy (HRT) use and increased risk of breast cancer is still under debate. Functionally relevant genetic variants within the estrogen metabolic pathway may alter exposure to exogenous sex hormones and affect the risk of postmenopausal breast cancer. We investigated the associations of common polymorphisms in 4 genes encoding key proteins of the estrogen...

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Share to Aryl Hydrocarbon Hydroxylases
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1B1

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Source

Identifiers

PMID: 21567099
DOI: 10.3892/or.2011.1298

Genes

COMT
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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