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Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors

1 Jan 2005

Abstract excerpt

Tumors lacking DNA mismatch repair activity (MMR) from patients with Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or those with sporadic colorectal cancer can be identified by the presence of high levels of instability in repetitive sequences known as microsatellites (MSI). The assessment of MSI phenotype in human tumors helps to establish a clinical diagnosis and is accomplished with a reference panel of...

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PMID: 16240453
DOI: 10.1002/mc.20146

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